vs 

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"How do you do" is a form of "how do you do", a phrase which is often translated as "cómo lo haces". "What" is a form of "what", a pronoun which is often translated as "qué". Learn more about the difference between "how do you do" and "what" below.
how do you do(
hau
 
du
 
yu
 
du
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. cómo lo haces (with a pronoun)
I love this yoga pose. - Wow! How do you do that without hurting your back?Me encanta esta pose de yoga. - ¡Vaya! ¿Cómo lo haces sin lastimarte la espalda?
b. cómo haces
How do you do your homework so late at night?¿Cómo haces tus deberes tan tarde en la noche?
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what(
wuht
)
A pronoun is a word that stands in for a noun (e.g., she).
pronoun
a. qué
What do you want me to do?¿Qué quieres que haga?
b. cuál
What was the reason for Jim's departure?¿Cuál fue la razón por la que se fuera Jim?
c. cómo
What's the weather like where you are?¿Cómo está el tiempo donde estás tú?
What's their house like?¿Cómo es su casa?
a. lo que
He smoked what he had left in his pipe.Se fumó lo que le quedaba en la pipa.
An adjective is a word that describes a noun (e.g., the big dog).
adjective
a. qué
What movie did you want to see?¿Qué película querías ver?
a. qué
What a nice day!¡Qué bonito día!
An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g., Wow!).
interjection
a. qué
What? That can't be true!¿Qué? ¡No puede ser verdad!
a. qué
What? Speak louder, please.¿Qué? Hable más alto, por favor.
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